Bioinformatic Data and Pathway Analysis
Technology
Functional Data & Presentations
Cellecta has partnered with Ariadne to offer a comprehensive Pathway Analysis service for downstream analysis of high-throughput (HT) RNAi genetic screen data. The computational validation of positive shRNA clones aims to find plausible signaling mechanisms connecting the effect of inhibition of siRNA target protein and observed phenotype. Searches against the comprehensive database of pathways and protein interactions are used to report:
- The lists of pathways affected by each of the identified shRNA clones.
- The common pathways, downstream events or upstream regulators for the sets of siRNAs.
- Expression profiles for corresponding genes as available from the public datasets.
- Similar biological effects of siRNA targets or other functionally related genes if known in the literature.
Fig. 1. Analysis of RNAi screen HT Sequencing data by Ariadne Pathway Studio® software. Interactively build pathways from HT sequencing data and visualize them in color and according to cellular localization.
As an option, the analysis results can be delivered in a format compatible with the software package Pathway Studio® to enable additional analysis of pathways involved and integration with the prior knowledge and profiling data.
Scientists with background and experience second-to-none make Cellecta a leader in the functional genomics service industry. By offering a complete package of functional analysis services, we can now be your single source to help take you and your lab from phenotype to gene to pathway to publication.
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