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Cellecta Event at ASHG 2017

Development of Novel Functional Genomic Tools for Identifying Candidate Disease Genes and Biomarkers

Join us for a lunch workshop on Wednesday, October 18 from 12:30 -1:30 pm, Lake George Room, Lobby Level, Hilton Orlando

Learn about:

  • new functional genomics technologies to understand complex diseases
  • simple workflow for biomarker discovery in whole blood
  • rapid method for assessment of immune status using blood transcriptomics

Presentations:

Development of Novel Synergistic Functional Genomics Technologies to Understand Complex Diseases
Alex Chenchik Research Director; Cellecta, Inc., Mountain View, CA

Advances in functional genomics will depend on innovative, high-throughput technologies that can be easily transferred from dedicated research centers to individual basic research and clinical laboratory settings. We will describe:

  • the development of a novel targeted RNA-Seq assay and data analysis workflow (DriverMap assay) to capture the complexities of human diseases
  • practical aspects of DriverMap and outline future applications
  • the identification of novel genes involved in tumor progression and metastasis in a preclinical mouse model using the DriverMap assay workflow and orthogonal, complementary functional genomic tools

Assessment of Immune Status and Biomarker Discovery Using Blood Transcriptomics
Lester Kobzik, M.D., Professor of Pathology, Brigham Women’s Hospital, Harvard Medical School, Harvard School of Public Health

Peripheral blood cells are now widely used as a surrogate tissue in many studies for reasons of accessibility and low risk related to its collection, as compared to invasive organ biopsies. Accordingly, profiling gene transcripts in whole blood (WB) have earned its place in the molecular and cellular profiling approaches used to analyze immune responses in samples from a broad range of diseases.To identify transcripts in WB that can potentially be employed as biomarkers, we need to utilize a technology that is highly sensitive and provides accurate quantification of RNA species. A simple strategy has been developed that enables:

  • more sensitive and precise hybrid of multiplex RT-PCR and digital RNA sequencing
  • streamlined workflow that allows direct and seamless conversion of candidate biomarkers to digital PCR-based diagnostic assays
  • development and implementation of a novel biomarker panel facilitating routine early sepsis detection in a rapid, cost-effective manner.

Lunch will be provided. We look forward to seeing you there.

Where: Lake George Room, Lobby Level, Hilton Orlando

When: Wednesday, October 18, 2017 –12:15 to 1:45 pm

12:15 pm   Registration and Lunch

12:30 – 1:00 pm  Dr. Alex Chenchik: Development of Novel Synergistic Functional Genomics Technologies to Understand Complex Diseases

1:00 – 1:30 pm  Dr. Lester Kobzik: Assessment of Immune Status and Biomarker Discovery Using Blood Transcriptomics

1:30 – 1:45 pm  Question & Answer period

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