The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and CRISPR-associated (Cas) genes denoted as the CRISPR/Cas9 system is a targeted gene-editing tool adapted from Streptococcus pygogenes that can be used to permanently knock out target genes. Guide RNAs (sgRNA or gRNA) direct the Cas9 nuclease to a specific genomic region upon which Cas9 cleaves the target gene, permanently knocking it out.
Cellecta has developed effective, time-saving tools for functional gene analysis using CRISPR technology.
|Cellecta’s CRISPR Human Genome Knockout Libraries provide ready-to-use, lentiviral-based, pooled sgRNA libraries that target all of the nearly 20,000 protein-encoding genes in the human genome.|
|CRISPR-Test Cas9 Assay Kits enable accurate assessment of Cas9 activity in human and other mammalian cells.|
|We also offer several lentiviral Cas9 Expression Plasmids that can be used to make Cas9+ cells for CRISPR screens, or targeted gene knockout experiments. In addition, to support these application,s we offer a panel of CRISPR control constructs and sgRNA Cloning Vectors|