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Publications

Browse the comprehensive list of publications from customers using Cellecta’s products and services, review articles, and other Cellecta research.

Cellecta and Customer Publications (as of July 2018)

InstitutionDisease/Pathway ListedTitleAuthorsYearCellecta Product/Service UsedBibliographyProduct Catalog Number
EPIZYMECancerSmall molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferationThomenius M, Totman J, Harvey D, Mitchell LH, Riera TV, Cosmopoulos K, Grassian AR, Klaus C, Foley M, Admirand EA, Jahic H, Majer C, Wigle T, Boriack-Sjodin, PA, et al.2018Custom CRISPR sgRNA library,
custom sgRNA constructs,
next-gen sequencing service
PLoS One. 2018 Jun 1;13(6):e0197372. doi: 10.1371/journal.pone.0197372. eCollection 2018. PMID: 29856759a. CPLVSHL-P b. CVSGC-DES c. CANA-SQD
GENENTECHNon-small cell lung cancer (NSCLC) CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLCDompe N, Klijn C, Watson SA, Leng K, Port J, Cuellar T, Watanabe C, Haley B, Neve R, Evangelista M, Stokoe D2018Custom CRISPR sgRNA libraryPLoS ONE 13(6): e0199264. PMID: 29912950CPLVSHL-P
University of Southern California, Case Western Reserve UniversityHIVHIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latencyLlewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM2018DECIPHER shRNA Library Human Modules 1, 2, 3J Neurovirol. 2018 Apr;24(2):192-203. PMID: 29256041HGW-M123-P2
Fordham Universitycell migration, cytokinesis, and apoptosisMyosin II–interacting guanine nucleotide exchange factor promotes bleb retraction via stimulating cortex reassembly at the bleb membraneJiao M, Wu D, Wei Q2018vectorMol Biol Cell. 2018 Mar 1;29(5):643-656. PMID: 29321250CVCRC-PX
The Netherlands Cancer Institute, Genmab, Leiden University Medical CenterMelanoma, lung, pancreas and cervical cancerCooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitorsBoshuizen J, Koopman LA, Krijgsman O, Shahrabi A, van den Heuvel EG, Ligtenberg MA, Vredevoogd DW, Kemper K, Kuilman T, Song JY, Pencheva N, Mortensen JT, Foppen MG, Rozeman EA, Blank CU, Janmaat ML, Satijn D, Breij ECW, Peeper DS, Parren PWHI2018CRISPR constructNat Med. 2018 Feb;24(2):203-212. PMID: 29334371CVSGC-DES
Dana-Farber Cancer Institute, The Institute of Cancer Research, Baylor College of Medicine, Harvard Medical School, Novartis Institute for Biomedical ResearchNeuroblastomaEnhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastomaZeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE2018Custom constructsNat Genet. 2018 Apr;50(4):515-523. PMID: 29379199CVSGC-DES
Boston University School of Medicine, The Affiliated Hospital of Qingdao University, MD Anderson Cancer Center, ActivSignal, Ariel UniversityCancerCancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinationsYaglom JA, Wang Y, Li A, Li Z, Monti S, Alexandrov I, Lu X, Sherman MY2018DECIPHER shRNA library Human Module 1Sci Rep. 2018 May 2;8(1):7177.HGW-M1-P2
GENENTECH, Princeton Universitytissue injury, degeneration, inflammationCRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicingCallow MG, Watanabe C, Wickliffe KE, Bainer R, Kummerfield S, Weng J, Cuellar T, Janakiraman V, Chen H, Chih B, Liang Y, Haley B, Newton K, Costa MR2018custom genome-wide CRISPR sgRNA libraryCell Death Dis. 2018 Feb 15;9(3):261. PMID: 29449584CPLVSGL-P
GENENTECHInflammationASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophagesLee BL, Mirrashidi KM, Stowe IB, Kummerfeld SK, Watanabe C, Haley B, Cuellar TL, Reichelt M, Kayagaki N2018Custom genome-wide CRISPR sgRNA librarySci Rep. 2018; 8: 3788. PMID: 29491424CPLVSGL-P
Duke-NUS Medical School, Institute of Molecular and Cell Biology Singapore, National Cancer Centre Singapore, National University of SingaporeBreast cancerFunctional genomics identifies specific vulnerabilities in PTEN-deficient breast cancerTang YC, Ho SC, Tan E, Tian Ng AW, McPherson JR, Lin Goh GY, The BT, Bard F, Rozen SG2018Custom shRNA library,
next-gen sequencing service
Breast Cancer Res. 2018; 20: 22. PMCID: PMC5863852a. CPLVSHL-P b. CANA-SQD
Hannover Medical School, Imperial College LondonCell proliferationA large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferationBeermann J, Kirste D, Iwanov K, Lu D, Kleemiß F, Kumarswamy R, Schimmel K, Bär C, Thum T2018custom shRNA library screen targeting lncRNACell Death Differ. 2018 Feb;25(2):307-318. PMID: 29099486CPLVSHL-P
Karolinska Institute, Karolinska University HospitalAcute Myeloid Leukemia (AML)The Chromatin-Remodeling Factor CHD4 Is Required For Maintenance Of Childhood Acute Myeloid LeukemiaHeshmati Y, Turkoz G, Harisankar A, Kharazi S, Bostrom J, Kamali Dolatabadi E, Krstic A, Chang D, Mansson R, Altun M, Qian H, Walfridsson J2018DECIPHER shRNA Library Human Module 2 and DECIPHER shRNA Library Mouse Module 2Haematologica. 2018 Mar 29. PMID: 29599201a. HGW-M2-P2 b. DMDAC-M2V2-P
CRO Aviano National Cancer Institute, Leiden University, IRCCS Scientific Institute San RaffaeleBreast cancerA p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressivenessdi Gennaro A, Damiano V, Brisotto G, Armellin M, Perin T, Zucchetto A, Guardascione M, Spaink HP, Doglioni C, Snaar-Jagalska BE, Santarosa M, Maestro R2018pRSI9 vectorCell Death Differ. 2018 Apr 17. doi: 10.1038/s41418-018-0103-x. PMID: 29666469CVSHC-PX
Huntsman Cancer Institute, ARUP Laboratories, University of UtahMyelofibrosisAutocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashionHeaton WL, Senina AV, Pomicter AD, Salama ME, Clair PM, Yan D, Bell RN, Gililland JM, Prchal JT, O'Hare T, Deininger MW2018inducible shRNA constructsLeukemia. 2018 Apr 18. doi: 10.1038/s41375-018-0131-z. PMID: 29749399CVSHC-PX
Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon; Yonsei University College of MedicineNon-small cell lung cancer (NSCLC)RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-κB-mediated ERK reactivationCho JH, You YM, Yeom YI, Lee DC, Kim BY, Won M, Cho BC, Kang M, Park S, Yang SJ, Kim JS, Kim JA, Park KC2018DECIPHER shRNA Library Human Module 1, lentiviral packaging plasmid mixCell Death Dis. 2018 Jun; 9(6): 587. PMID: 29789542a. HGW-M1-P2 b. CPCP-K2A
Technische Universität Dresden, University of Copenhagen, Leibniz Institute for Experimental Virology, Heidelberg and German Cancer Consortium, University of Frankfurt, Max Planck Institute of Molecular Cell Biology and GeneticsAcute Myeloid Leukemia (AML)STK3 is a therapeutic target for a subset of acute myeloid leukemiasCamgoz A, Paszkowski-Rogacz M, Satpathy S, Wermke M, Hamann MV, von Bonin M, Choudhary C, Knapp S, Buchholz F, et al.2018pRSI12 vectorOncotarget. 2018 May 22;9(39):25458-25473. PMID: 29876001CVSHC-PX
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan; Aichi Cancer Center Research Institute, Nagoya, Japan. ; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. ; The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ; The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA. ; Ohio State University, Columbus, OH, USA. ; Fujita Health University, Toyoake, Japan.Lung CancereIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer.Tanaka ,Sato M, Kato T, Goto D, Kakumu T, Miyazawa A, Yogo N, Hase T, Morise M, Sekido Y Girard L, Minna JD, Byers LA, Heymach JV, Coombes KR, Kondo M, Hasegawa Y, et al.2018Human Genome-Wide Lentiviral shRNA Library Module 1Cancer Sci. 2018 Jun; 109(6):1843-1852. Epub 2018 May 25; PMID: 29624814HGW-M1-P2
The University of Texas MD Anderson Cancer Center; Harvard Medical School, BostonLung CancerIncreased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.Cascone T, McKenzie JA, Mbofung RM, Punt S, Wang Z, Xu C,
Williams LJ, Wang Z,
et al.
2018U6 shRNA/sgRNA promoter,
Human Genome-Wide Lentiviral shRNA Library,
Lentiviral Packaging Plasmid Mix
Cell Metab. 2018 May 1;27(5):977-987.e4. doi: 10.1016/j.cmet.2018.02.024. Epub 2018 Apr 5. ; PMID: 29628419a. HGW-M123-P2 b. CPCP-K2A
Kagoshima University, Nanpuh Hospital, Kyushu Institute of TechnologycancerA novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analysesKamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T2018DECIPHER shRNA Library Human Module 1,
next-gen sequencing service, plasmid packaging mix
Oncoscience. 2018 Apr 29;5(3-4):88-98. PMID: 29854877a. HGW-M1-P2 b. CANA-SQD c.CPCP-K2A
Genetic Engineering & Biotechnology News (GEN) Pushing the Boundaries of CRISPR: Innovations in Genome Editing on Multiple FrontsSeydel C2018TechnologyGEN: June 01, 2018 (Vol. 38, No. 11)
Portland State UniversityAcute Myeloid Leukemia (AML)Inhibition of Interleukin-1 Receptor-Associated Kinase-1 is a Therapeutic Strategy for Acute Myeloid Leukemia SubtypesMohammadhosseini M2018Custom shRNA libraryPortland State University PDXScholarCPLVSHL-P
Novartis Institutes for BioMedical Research, Novartis Pharma AGasthma, COPD, cystic fibrosisTRRAP is a central regulator of human multiciliated cell formationWang Z, Plasschaert LW, Aryal S, Renaud NA, Yang Z, Choo-Wing R, Pessotti AD, Kirkpatrick ND, Cochran NR, Carbone W, Maher R, Lindeman A, Russ C, Reece-Hoyes J, McAllister G, Hoffman GR, Roma G, Jaffe AB2018Custom shRNA libraryJ Cell Biol. 2018 Jun 4;217(6):1941-1955. PMID: 29588376CPLVSHL-P
University of Heidelberg, Heidelberg, Germany; Institute for Medical Informatics, Leipzig, Germany; Technical University of Munich, Germany; Division of Applied Bioinformatics, DKFZ, Heidelberg, Germany; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; Cellecta, Inc., Mountain View, CA 94043;Immune Cell Cancer MDM4 is an essential disease driver targeted by 1q gain in Burkitt lymphomaJennifer Huellein, Mikolaj Slabicki, Maciej Rosolowski, Alexander Jethwa, Stefan Habringer, Katarzyna Tomska, Roma Kurilov, Junyan Lu2018Human Genome-Wide Lentiviral shRNA LibrarybioRxiv 289363; doi: https://doi.org/10.1101/289363HGW-M123-P2
Cornell UniversityStress responsem6A Facilitates eIF4F-Independent mRNA TranslationCoots RA, Liu XM, Mao Y, Dong L, Zhou J, Wan J, Zhang X, Qian SB2017pRSI9 vectorMol Cell. 2017 Nov 2;68(3):504-514.e7. PMID: 29107534CVSHC-PX
Roswell Park Cancer Institute, Ariel University, Buffalo BioLabs, Blokhin Cancer Research Center RAMSCancerTranscription of Repeats Activates INterferon (TRAIN) in response to
chromatin destabilization induced with anti-cancer small molecule
Leonova K, Safina A, Nesher E, Sandlesh P, Pratt R, Burkhart C, Lipchick B, Gitlin I, Frangou C, Koman I, Wang J, Kirsanov K, Yakubovskaya MG, Gudkov AV, Gurova K2017Custom reporter vectorElife. 2018 Feb 5;7. PMID: 29400649CVPRC-PX
Novartis Institutes for Biomedical Research, Dana-Farber Cancer InstituteOvarian CancerRecurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin CKedves AT1, Gleim S1, Liang X1, Bonal DM2, Sigoillot F1, Harbinski F1, Sanghavi S3, Benander C1, George E1, Gokhale PC2, Nguyen QD2, Kirschmeier PT2, Distel RJ2, Jenkins J1, Goldberg MS2, Forrester WC1.2017constructsJ Clin Invest. 2017 Dec 1;127(12):4554-4568. PMID: 29130934CVSHC-PX
Ohio State University, The University of Texas,Nagoya UniversityLung CancerIdentification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancerKakumu T, Sato M, Goto D, Kato T, et al.2017Lentiviral shRNA librariesCancer Sci. 108(4):732-743. PMID: 28165654CPLVSHL-P
KeioUniversity,PRESTO, Nagoya University CancerProtein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitorShikata Y, Yoshimaru T, Komatsu M, et al.2017Custom ConstructsCancer Sci. 108(4):785-794. PMID: 28122154CVSHC-PX
Weizmann Institute of Science, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology,RehovotCancerSignalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death Dasari SK, Bialik S, Levin-Zaidman S, et al.2017Lentiviral shRNA librariesCell Death Differ. 24(7):1288-1302. PMID: 28574511CPLVSHL-P
STANFORD SCHOOL OF MEDICINE, OHSU, HUNSTMANAcute Myeloid leukemiaIdentification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid LeukemiaCarey A, Edwards DK, Eide CA, Newell L, et al.2017Custom Lentiviral Tet-Inducible shRNA libraryCell Rep 18(13):3204-3218. PMID: 28355571CPLVSHL-P
NOVARTISAmyotrophic lateral sclerosis (ALS)Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9Goodwin JM, Dowdle WE, DeJesus R, Wang R, et al.2017Custom Human Genome-Wide Lentiviral CRISPR sgRNA LibraryCell Rep 20(10):2341-2356.PMID: 28877469CPLVSHL-P
CHEMICAL GENOMICS RESEARCH GROUP, RIKEN CENTER FOR SUSTAINABLE RESOURCE SCIENCECell DeathA quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide BShohei Takase, Rumi Kurokawa, Daisuke Arai,
et al.
2017DECIPHER shRNA Librarydoi:10.1038/s41598-017-02016-4HGW-M123-P2
University of Málaga and IBIMA, Málaga,
Harvard Medical School, University of Texas at Dallas, University of Nebraska, University of Colorado, Stony Brook Medicine
Pancreatic CancerMUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic CancerSurendra K. Shukla, Vinee Purohit, et al.2017Custom Constructshttps://doi.org/10.1016/j.ccell.2017.06.004CVCRCC-PX
Institute of Carcinogenesis, Blokhin Cancer Research Center RAMS, Roswell Park Cancer Institute, Buffalo BioLabs, Ariel UniversityCancerTRAIN in response to treatment with anti-cancer small molecule destabilizing chromatinLeonova Y, Safina A, Nesher E, et al.2017CRISPR sgRNA libraryhttps://doi.org/10.1101/142471a. CPLVSGL-P b. CRGC
GENENTECHAcute Myeloid LeukemiaSilencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemiaCuellar TL, Herzner AM, Zhang X, Goyal Y, et al.2017Custom Epi sgRNA libraryJ Cell Biol Sep 2017, jcb.201612160. PMID: 28887438CPLVSGL-P
Icahn School of Medicine at Mount Sinai, Albert Einstein College of Medicine-Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein αSong Z, Xiaoli AM, Zhang Q, Zhang Y, et al.2017Custom ConstructsJ. Biol. Chem. 292(21):8918-8932. PMID: 28351837CVCRCC-PX
Princess Margaret Cancer Centre, University of California at Berkeley, Stanford University CancerSystematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor dataSinha S, Thomas D, Chan S, Gao Y, Brunen D, et al.2017Lentiviral shRNA librariesNat Commun 8:15580. PMID: 28561042CPLVSHL-P

Drug Safety and Pharmacology, Pfizer Inc., ORIC Pharmaceuticals, South San FranciscoCancerTargeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A• Quinlan CL, Kaiser SE, Bolaños B, Nowlin D, et al.2017Custom ConstructsNat. Chem. Biol. 13(7):785-792. PMID: 28553945CVCRCC-PX
DKFZ, DKTK,
Edison Family Center for Genome Sciences &Systems Biology, Washington University School of Medicine,University of Freiburg Medical Center
-DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeatsBrocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, et al.2017Custom ConstructsNat. Genet. 49(7):1052-1060. PMID: 28604729CVCRCC-PX
Caribou Biosciences, Berkeley, California, USA, DuPont Pioneer, Johnston, Iowa, USA.-Mapping the genomic landscape of CRISPR-Cas9 cleavageCameron P, Fuller CK, Donohoue PD, Jones BN, et al.2017Lentiviral CRISPR sgRNA LibraryNat. Methods 14(6):600-606. PMID: 28459459CPLVSGL-P
Oncology Research and Development, Pfizer, ORIC PharmaceuticalsCancerTargeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2ACasey L Quinlan, Stephen E Kaiser, et al.2017Custom ConstructsNature Chemical Biology 13, 785–792 (2017) doi:10.1038/nchembio.2384CVCRCC-PX
RIKEN, AMED-CREST, Meiji University, Research Institute for Science and Engineering, Waseda University, College of Micronesia- A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide BTakase S, Kurokawa R, Arai D, Kanemoto Kanto K, et al.2017Lentiviral shRNA librariesSci Rep 7(1):2002. PMID: 28515454CPLVSHL-P
NOVARTISMultiple CancersOnline supplemental materials for: Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cellsEstoppey D, Hewett JW, Guy CT, Harrington E, et al.2017Custom Human Genome-Wide Lentiviral CRISPR sgRNA LibraryScientific Reports 16(7):42728.CPLVSGL-P
Novartis Institutes for Biomedical Research, Harvard Medical SchoolAmyotrophic lateral sclerosis (ALS)Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9Goodwin JM, Dowdle WE, DeJesus R, Wang Z, Bergman P, Kobylarz M, Lindeman A, Xavier RJ, McAllister G, Nyfeler B, Hoffman G, Murphy LO2017Custom genome-wide sgRNA libraries,
packaging mix
Cell Rep. 2017 Sep 5;20(10):2341-2356. PMID: 28877469a. CPLVSGL-P, b. CPCP-K2A
NOVARTIS, DANA-FARBERProstate cancerERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the androgen receptorMounir Z,Korn JM, Westerling T, Lin F, Kirby CA, et al.2016Lentiviral shRNA librariesElife. 2016 May 16;5. pii: e13964. doi: 10.7554/eLife.13964. [Epub ahead of print] PubMed PMID: 27183006.CPLVSHL-P
NOVARTISPaget disease
Neurodegeneration
Metabolic dysfunction
Cancer
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62DeJesus R,Moretti F, McAllister G, Wang Z, et al.2016CRISPR sgRNA library2016 Jun 28;5. pii: e17290. doi: 10.7554/eLife.17290. PubMed PMID: 27351204a. CPLVSHL-P, b.CPLVSGL-P
IEO, C4 THERAPEUTICS, THE UNIVERSITY OF TEXAS-MD ANDERSON CANCER CENTER,IITPancreatic cancerIn Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic CancerCarugo A,Genovese G, Seth S, Nezi L, Rose JL, et al.2016Lentiviral shRNA librariesCell Rep. 2016 Jun 16. pii: S2211-1247(16)30661-1. doi: 10.1016/j.celrep.2016.05.063. [Epub ahead of print] PubMed PMID: 27320920.CPLVSHL-P
NCT, DKFZBurkitt's lymphomaDissection of CD20 regulation in lymphoma using RNAiSlabicki M,Lee KS, Jethwa A, Sellner L, Sacco F, et al.2016Lentiviral shRNA librariesLeukemia. 2016 Sep 20. doi: 10.1038/leu.2016.230. [Epub ahead of print] PubMed PMID: 27560109.CPLVSHL-P
NOVARTIS,UNIVERSITY OF WASHINGTONLung cancerTankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP SignalingWang H,Lu B, Castillo J, Zhang Y, et al.2016Lentiviral vectorJ Biol Chem. 2016 Jul 15;291(29):15256-66. doi: 10.1074/jbc.M116.722967. Epub 2016 May 26. PubMed PMID: 27231341.CVSHC-PX
IEO(EUROPEAN INSTITUTION OF ONCOLOGY),IITMetastatic melanomaIn Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed PhenotypeBossi D,Cicalese A, Dellino GI, Luzi L, Riva L, et al.2016Lentiviral shRNA libraries
Lentiviral packaging plasmid mix or shRNA knockdown construct
2016 May 13. [Epub ahead of print] PubMed PMID: 27179036.a. CPLVSHL-P b. CPCP-K2A, c. CVSHC-PX
Cellecta,
Department of Cell Stress Biology, Cancer Institute, Buffalo,
Buffalo BioLabs, LLC, Sanford-Burnham-Presby Medical Discovery Institute
Cell Death Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failureKomarov AP, Komarova EA, Green K, et al.2016shRNA libraryCell Death Dis. 2016 Mar 17;7:e2145. doi: 10.1038/cddis.2016.45. PubMed PMID: 26986512.CPLVSHL-P
Cellecta Biomarker Discovery Gets a Fix on CancerKathy Liszewski2016TechnologyGenetic Engineering & Biotechnology News. January 2016, 36(3): 1, 12-13. doi:10.1089/gen.36.03.01.
Institute for Microbiology and Hygiene, Charité University Medical Center BerlinAging TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians – A cohort study. Hamann L, Bustami J, Iakoubov L, et al.2016CollaborationImmun Ageing. 2016 Mar 17;13:7. doi: 10.1186/s12979-016-0062-3. eCollection 2016. PubMed PMID: 26997964; PubMed Central PMCID: PMC4797164.
CELGENE
Multiple MyelomaRate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4
Bjorklund CC, Lu L, Kang J, Hagner PR, et al.2015
Custom Lentiviral Tet-Inducible shRNA Constructs
Blood Cancer J 5:e354. PMID: 26430725CVSHC-PX
EPIZYMECancerA Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene EssentialityGrassian AR, Scales TM, Knutson SK, et al.2015sgRNA pRSGC1-U6-sg-CMV-Cas9-2A-Puro plasmid and lentivirus2015 Nov 14;17:15. eCollection 2015. PubMed PMID: 26578851; PubMed Central PMCID: PMC4647477.CVCRCC-PX
STANFORD SCHOOL OF MEDICINE, LELAND STANFORD JUNIOR UNIVERSITYMyeloid leukemiaIsocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemiaChan SM, Thomas D, Corces-Zimmerman MR, et al.2015DECIPHER pRSI9-U6-sh-UbiC-TagRFP-2A-Puro vector
DECIPHER shRNA Library Human Module 1
Nat. Med. 21(2):178-84. PMID: 25599133a. CVSHC-PX, b. HGW-M1-P2
NOVARTISLung cancerInhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung CancerLantermann AB,Chen D, McCutcheon K, et al2015shRNA (stem loop sequence GTTAATATTCATAGC)Res. 75(22):4937-48. PMID: 26490646CVSHC-PX
HUNTSMAN, THE UNIVERSITY OF UTAH, CELLECTALeukemiashRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistanceKhorashad JS,Eiring AM, Mason CC, Gantz KC, et al.2015Lentiviral shRNA library HM12015 Mar 12;125(11):1772-81. doi: 10.1182/blood-2014-08-588855. Epub 2015 Jan 8. PubMed PMID: 25573989; PubMed Central PMCID: PMC4357584.HGW-M1-P2
AMGENBreast cancerSLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the CytoplasmHamblett KJ,Jacob AP, Gurgel JL, Tometsko ME, et al.2015Lentiviral shRNA libraries75(24):5329-40. PMID: 26631267HGW-M1-P2
Cellecta New Genome-wide functional analysis tools needed to accelerate drug development.Diehl P.2015TechnologyChimica Oggi-Chemistry Today: Vol 33(1): January/February 2015.
SANOFI, REGULUSLiver Cancer Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cellsWagenaar TR, Tolstykh T, Shi C, et al.2015DECIPHER shRNA Library: Human Module 1Nucleic Acids Res. 2015 Jan;43(2):1204-15. doi: 10.1093/nar/gku1367. EpubHGW-M1-P2
SALKLung cancerScreening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinomaYeddula N,Xia Y, Ke E, Beumer J, Verma IM2015DECIPHER shRNA Library Mouse Module 1Proc. Natl. Acad. Sci. U.S.A. 112(47):E6476-85. PMID: 26542681DMPAC-M1V2-P
NOVARTIS, BIOZENTRUMMelanomaMaximizing the efficacy of MAPK-targeted treatment in PTENLOF/BRAFMUT melanoma through PI3K and IGF1R inhibitionHerkert B,Kauffmann A, Mollé S, et al.2015Lentiviral shRNA librariesRes. PMID: 26577700CPLVSHL-P
QUEEN MARY-UNIVERSITY OF LONDON, CNIOPancreatic CancerMYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem CellsSancho P, Burgos-Ramos E, Tavera A, et al.2015lentiviral shRNACell Metab. 22(4):590-605. PMID: 26365176CVSHC-PX
MUSC-MEDICAL UNIVERSITY OF SOUTH CAROLINABreast cancerOncogenic signaling in Amphiregulin and EGFR-expressing PTEN-null human breast cancerKappler CS,Guest ST, Irish JC, Garrett-Mayer E2014Ready-to-Use Packaging Mix (Cat #CPCP-K2A)
DECIPHER shRNA Libraries Human Modules 1, 2, 3
Molecular Oncology. DOI: 10.1016/j.molonc.2014.10.006a. HGW-M123-P2, b. CPCP-K2A
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo,Cellecta, Inflammation Peptides genetically selected for NF-κB activation cooperate with oncogene Ras and model carcinogenic role of inflammationNatarajan V, Komarov AP, Ippolitoa T, Bonneau K, Chenchik AA, Gudkov AV.2014CollaborationPNAS. 111(4):E474-83. PMID:24474797
DKFZ-GERMAN CANCER RESEARCH CENTER, PRINCETON UNIVERSITYHereditary Leiomyomatosis & Renal Cell CarcinomaHigh throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cellsBoettcher M, Lawson A, Ladenburger V, et al.2014DECIPHER shRNA Libraries Human Modules 1, 2
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BMC Genomics. 15(1):158. PMID: 24568598a. HGW-M1-P2, b. HGW-M2-P2
(MTC), Karolinska Institutet, Northeast Agricultural University,Department of Cell Stress Biology, Roswell Park Cancer Institute,Cellecta, Inc.Cell Death Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosisLi H, Zhang Y, Ströse A, Tedesco D, Gurova K, Selivanova G.2014shRNA LibraryCell Death Differ. PMID: 24971482CPLVSHL-P
CellectaGenetic Engineering & Biotechnology NewsGreg Crowther.2014Technologydoi:10.1089/gen.34.20.09.
Cellecta Use of RNAi screens to uncover resistance mechanisms in cancer cells and identify synthetic lethal interactions.Diehl P, Tedesco D, Chenchik A2014TechnologyDrug Discovery Today: Technologies, In Press, Available online 7 January 2014.
Cellecta, Mossakowski Medical Research Centre, Polish Academy of Sciences, Medical Center of Postgraduate EducationAging A Common Copy Number Variation Polymorphism in the CNTNAP2 Gene: Sexual Dimorphism in Association with Healthy Aging and DiseaseIakoubov L, Mossakowska M, Szwed M, Puzianowska-Kuznicka M.2014CollaborationGerontology. DOI: 10.1159/000363320
UAB, GRU, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAICancerTranscriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African AmericansWeige CC, Birtwistle MR, Mallick H, et al.2014DECIPHER shRNA Library Human Module 1Mol Cancer Res. 2014 Jul;12(7):1029-41. doi: 10.1158/1541-7786.MCR-13-0286-T. Epub 2014 Apr 17. PubMed PMID: 24743655; PubMed Central PMCID: PMC4101030.HGW-M1-P2
MUSC-MEDICAL UNIVERSITY OF SOUTH CAROLINABreast cancerKAT6A, a Chromatin Modifier from the 8p11-p12 Amplicon is a Candidate Oncogene in Luminal Breast CancerTurner-Ivey B, Guest ST, Irish JC, Kappler CS, et al.2014DECIPHER shRNA Libraries Human Modules 1, 2, 3Neoplasia 16(8):644-55. PMID: 25220592HGW-P2
NOVARTIS, DANA-FARBERCancer (BRG-1 deficient)Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancersHoffman GR,Rahal R, Buxton F, Xiang K, McAllister G, et al.2014Lentiviral shRNA librariesPNAS. PMID: 24520176CPLVSHL-P
DKFZ-GERMAN CANCER RESEARCH CENTERBreast cancerA mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype.Wolf J, Dewi D, Fredebohm JA, Muller-Decker K, et al.2013DECIPHER RNAi Library Module 1
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Breast Cancer Research. 15:R109 doi:10.1186/bcr3576.a. HGW-M1-P2
Department of Cell Stress Biology, Roswell Park Cancer Institute,Tauber Bioinformatics Research Center,Cellecta, Lerner Research Institute, Cleveland ClinicTumor p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAsLeonova KI, Brodsky L, Lipchick B, Pal M, Novototskaya L, Chenchik AA, Sen GC, Komarova EA, Gudkov AV2013CollaborationProc Natl Acad Sci U S A. Jan 2;110(1):E89-98. doi:10.1073/pnas.1216922110. Epub 2012 Dec 10. PMID: 23236145
DKFZ-GERMAN CANCER RESEARCH CENTERPancreatic cancerDepletion of RAD17 sensitizes pancreatic cancer cells to gemcitabineFredebohm J, Wolf J, Hoheisel JD, Boettcher M2013DECIPHER shRNA Libraries Human Modules 1, 2
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J Cell Sci. Aug 1;126(Pt 15):3380-9. doi: 10.1242/jcs.124768. Epub 2013 May 17. PubMed PMID: 23687379.a. HGW-M1-P2, b. HGW-M2-P2
HUNTSMAN, KARYOPHARM, CELLECTAMyeloid leukemiaAn Unbiased shRNA Library Screen Identifies Nucleocytoplasmic Transport As a Potential Target For Treatment Of Chronic Myeloid LeukemiaKhorashad JS,Mason CC, Kraft IL, Reynolds KR, et al2013Lentiviral shRNA librariesBlood. 122(21):2707.HGW-M123-P2
Cellecta Human pluripotent stem cells: an emerging model in developmental biologyZhu, Z., & Huangfu, D2013TechnologyDevelopment. 140(4), 705-717.
Cellecta Advances in RNAi Tools and Technologies.Thalyana Smith-Vikos2013TechnologyGenetic Engineering & Biotechnology News. April 15, 2013, 33(8): 20-22, 24. doi:10.1089/gen.33.8.09.
DKFZ-GERMAN CANCER RESEARCH CENTER, MD ANDERSON CANCER CENTERBreast cancerAn in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulationWolf J, Muller-Decker K, Flechtenmacher C, et al.2013DECIPHER shRNA librariesOncogene. Advance online publication 2 December 2013; doi: 10.1038/onc.2013.515.HGW-M123-P2
AMGENGeneral CancerMeasurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor EngraftmentNolan-Stevaux O, Tedesco D, Ragan S, Makhanov M, et al.2013Custom shRNA Library: Human Module 1PLoS One. Jun 26;8(6):e67316. Print 2013. PMID: 23840661CPLVSHL-P
Stanford Cancer Institute,University of Miami Miller School of Medicine,Science Exchange Next-Generation Sequencing for High-Throughput RNA Interference Screens.Ward, T. M., Jegg, A. M., & Iorns, E2013TechnologyIn Next Generation Sequencing in Cancer Research. (pp. 287-299). Springer New York.
CellectaRNAi2013: RNAi at Oxford. Journal of RNAi and gene silencing: an international journal of RNA and gene targeting researchMulcahy, L. A., & Carter, D. R.2013TechnologyRNAi2013: RNAi at Oxford. Journal of RNAi and gene silencing: an international journal of RNA and gene targeting research, 9, 486.
Cellecta Capitalizing on miRNA Research.MaryAnn Labant2012TechnologyGenetic Engineering & Biotechnology News. June 15, 2012, 32(12): 1-28. doi:10.1089/gen.32.12.10.
Cellecta Cell Perturbation Screens for Target Identification by RNAi.Demir, K., & Boutros, M.2012TechnologyIn Bioinformatics and Drug Discovery. (pp. 1-13). Humana Press.
Cellecta RNA interference in mammals: behind the screenCampeau, E., & Gobeil, S.2011TechnologyBriefings in functional genomics. 10(4), 215-226.
Roswell Park Cancer Institute,Cellecta, Cleveland BioLabsProteotoxic stress Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomibNeznanov N, Komarov AP, Neznanova L, Stanhope-Baker P, Gudkov AV2011lentiviral vectorOncotarget. Mar;2(3):209-21. PubMed PMID: 21444945; PubMed Central PMCID: PMC3260823.CVSHC-PX
Roswell Park Cancer Institute, Cellecta,- Long-distance effects of insertional mutagenesis.Singhal R, Deng X, Chenchik AA, Kandel ES.2011CollaborationPLoS One. Jan 5;6(1):e15832. doi: 10.1371/journal.pone.0015832. PMID: 21246045
Department of Medical Genetics,Osaka University Graduate School of Medicine,B-Bridge International IncCell Death Screening of cell death genes with a mammalian genome-wide RNAi libraryTsujii H, Eguchi Y, Chenchik A, Mizutani T, Yamada K, Tsujimoto Y2010shRNA libraryJ Biochem. Aug;148(2):157-70. doi: 10.1093/jb/mvq042. Epub 2010 Apr 26. PubMed PMID: 20421362.CPLVSHL-P
Roswell Park Cancer Institute,Cellecta, Inc.,Cleveland BioLabs,Lerner Research InstituteProteotoxic stress Anti-malaria drug blocks proteotoxic stress response: anti-cancer implicationsNeznanov N, Gorbachev AV, Neznanova L, Komarov AP, Gurova KV, Gasparian AV, Banerjee AK, et al.2009CollaborationCell Cycle. Dec;8(23):3960-70. Epub 2009 Dec 25. PubMed PMID: 19901558; PubMed Central PMCID: PMC2923591.